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20 lis 2020 · Currently, the only accepted treatment for coeliac disease is a strict, life-long gluten-free diet (GFD), which usually results in the alleviation of symptoms and in improvement of...
BACKGROUND. Wheat and other gluten-containing grains are widely consumed, providing approximately 50% of the caloric intake in both industrialised and developing countries. The widespread diffusion of gluten-containing diets has rapidly led to a sharp increase in celiac disease prevalence.
Multiple investigational therapies ranging from tolerogenic to immunological approaches are in the pipeline, and several drug candidates have entered phase II/III clinical trials. This Review gives a broad overview of the different investigative treatment modalities for coeliac disease and summarizes the latest advances in this field.
Drug discovery for treating CD, as a complement to a GFD, aims to intervene in different scenarios, including (a) maintenance therapy, (b) rescue therapy after acute gluten exposure, and (c) the mitigation of inadvertent chronic gluten exposure [15].
At present, strict and lifelong gluten-free diet is the only effective treatment for celiac disease (1). Even small amounts of gluten (50 mg/day) can be immunogenic; therefore all food and food items and drugs that contain gluten and its derivatives must be eliminated from the diet completely (2). While prescribing gluten-free diet is easy; the ...
14 cze 2023 · Safety and tolerability of KAN-101, a liver-targeted immune tolerance therapy, in patients with coeliac disease (ACeD): a phase 1 trial
1 wrz 2024 · There are currently no treatment options for patients with CeD approved by the US Food and Drug Administration (FDA).
