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It is important to consider the risk of creating a zinc microenvironment that favors pathogen growth when zinc is supplemented during infection while interfering with the efforts of the innate system to chelate available free zinc.
Objective To evaluate the benefits and risks of zinc formulations compared with controls for prevention or treatment of acute viral respiratory tract infections (RTIs) in adults.
Conclusion: Currently, indirect evidence suggests zinc may potentially reduce the risk, duration and severity of SARS-CoV-2 infections, particularly for populations at risk of zinc deficiency including people with chronic disease co-morbidities and older adults.
1 gru 2020 · HDIVZn is a two-arm, double-blind RCT comparing intravenous zinc chloride (0.5 mg/kg/d) or placebo in 250 ml saline bags infused daily over 3−6 h for seven days. HDIVZn aims to recruit 160 patients who are hospitalised with SARS-CoV-2 infection. The primary outcome is oxygenation.
12 lut 2021 · Zinc has been purported to increase polymorphonuclear cells’ ability to fight infection, and ascorbic acid is an antioxidant that may play a role in immune response. 4,5 Limited evidence suggests that high doses of ascorbic acid and zinc gluconate may reduce duration of common cold symptoms and decrease the severity of symptoms. 6-9 However ...
Additionally, zinc has well-demonstrated protective effects against hypoxic injury—a clear mechanism of end-organ injury in respiratory distress syndrome. We aimed to assess the effect of high-dose intravenous zinc (HDIVZn) on SARS-CoV-2 infection.
Improved zinc intake may also reduce the risk of bacterial pneumonia co-infection by improving ciliary length and movement that affects viral particle removal and improves mucociliary clearance. There are many ways to supplement zinc through usual food consumption.
