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21 mar 2022 · Recent investigations indicated that citric acid and lipids—with a special emphasis on fatty acids, steroids and hormones (ex. prolactin)—play a significant role in prostate cancer development and progression.
29 maj 2024 · Citrate, a molecule closely linked to the unique metabolism of prostate cancer, has the potential to be used as a complementary biomarker alongside PSA. Prostate cancer accounts for ~15% of all...
1 sty 2020 · Zinc treatment could lead to citrate accumulation in malignant prostate cells, which could have therapeutic potential in clinical therapy of prostate cancer. There are also some ongoing efforts in developing inhibitors against the critical enzymes of citrate regulation as anti-cancer therapeutics.
Abstract. Prostate cancer is the most commonly diagnosed noncutaneous cancer in men in the United States. Treatment of men with prostate cancer commonly involves surgical, radiation, or hormone therapy. Most men with prostate cancer live for many years after diagnosis and may never suffer morbidity or mortality attributable to prostate cancer.
28 maj 2019 · Notably, citric acid was identified as one of the compounds present in CPEs that acts as a cell cycle re-entry inhibitor. Citric acid exhibited a higher cell toxicity effect on PC-3 prostate cancer cells than non-cancerous RWPE-1 prostate cells, suggesting specific benefits for cancer treatment.
Unlike most cancer cells that resort to aerobic glycolysis, prostate cancer cells exhibit a higher level of citric acid cycle activity compared to benign cells . Accumulation of zinc may also lead to a mitochondrial apoptotic phenotype within prostate cells.
27 lut 2020 · Prostate cancer therapies are improving over time. But how do the long-term side effects from the various options available today compare? Results from a newly published study are providing some valuable insights.
