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Signs of definitive chronic pancreatitis are parenchymal or intraductal calcifications, pancreatic fibrosis, exocrine and endocrine pancreatic insufficiency resulting in malabsorption and diabetes, pain, and an increased risk of pancreatic cancer. Quality of life (QOL) and life expectancy are also reduced.
3 sty 2023 · Patients with chronic pancreatitis (CP) is one of the major risk groups for pancreatic cancer, and the relative risk of pancreatic cancer in patients with CP has been reported to be as high as...
3 sty 2023 · CP is known as one of the major risk factors for pancreatic cancer. The SIRs of pancreatic cancer in patients with CP have been reported to be 7.6‒68.1 2 – 6. The age- and sex-SIR in our study was 18.1 (95% CI 10.4‒29.5), which also demonstrated that CP has higher risk for pancreatic cancer.
This report defines the diagnostic criteria useful in the assessment of patients with suspected and established chronic pancreatitis. All current diagnostic procedures are reviewed and evidence based statements are provided about their utility and limitations.
Heavy alcohol use and cigarette smoking are the most common environmental risk factors, but both may be absent. Antecedent episodes of acute pancreatitis occur in about half of patients, so active interventions are needed to reduce the risk of disease progression.
There is very little quality evidence suggesting performing screening examination for pancreatic malignancy in all patients and even in those at high risk for pancreatic malignancy due to genetic or environmental risk factors.
28 mar 2022 · Meta-analysis of 12 chronic pancreatitis (CP) studies demonstrated an increased risk of PDAC in patients with CP (SIR: 22.61, 95% confidence interval [CI]: 14.42-35.44). This elevated risk persisted in subgroup analysis of studies that excluded patients diagnosed with PDAC within 2 years of CP diagnosis (SIR: 21.77, 95% CI: 14.43-32.720).
