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P Casaccia-Bonnefil, BD Carter, RT Dobrowsky, MV Chao. Nature 383 (6602), 716-719, 1996. 1011: 1996: ... Journal of neuroscience 22 (23), 10333-10345, 2002. 344: 2002: Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.
Dr. Casaccia’s work adopts molecular and cellular techniques to understand how glial cells (more specifically myelinating oligodendrocytes) modify genes to acquire their identity and how the environment (i.e. social influences and physical space) may modify this process, thereby affecting myelin formation and disease susceptibility.
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Patrizia Casaccia is an Italian neuroscientist who is the Director of the Neuroscience Initiative of the Advanced Science Research Center at the CUNY Graduate Center, as well as a Professor of Neuroscience, Genetics & Genomics, and Neurology at the Icahn School of Medicine at Mount Sinai. Casaccia is a pioneer in the study of myelin.
27 sty 2022 · Casaccia, Einstein Professor of Biology at The Graduate Center and the founding director of the Neuroscience Initiative at the GC’s Advanced Science Research Center, is known for her research on the effects of environmental exposure on brain health.
Here we will introduce the concept of epigenetic regulation of gene expression, first in general and then focusing on the oligodendrocyte lineage. We will then review the current literature on mechano-transduction in distinct cell types, followed by pathways identified in myelinating oligodendrocytes and their progenitors.
J. Liu, K. Dietz, G.E. Hodes, S.J. Russo, P. Casaccia. Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress. Developmental neurobiology, 2018 Feb;78(2):152-162.. DOI: doi.org/10.1002/dneu.22533
