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4 wrz 2021 · The cardiac desmosome is classically thought to function as a cell-cell adhesive structure (Broussard et al. 2015); however, emerging evidence points to noncanonical roles for the cardiac desmosome in regulating electrical channels and function, independent of its classic structural roles.
Cardiac desmosomes and adherens junctions, in addition to gap junctions that provide open channels for electrical communication, are traditionally described as discrete components of intercalated discs connecting adjacent cardiac cells.
1 mar 2008 · Desmosomes are intercellular junctions of epithelia and cardiac muscle. They resist mechanical stress because they adopt a strongly adhesive state in which they are said to be hyper-adhesive and which distinguishes them from other intercellular junctions; desmosomes are specialised for strong adhesion and their failure can result in diseases of ...
18 lip 2023 · Desmosomes play a vital role in providing structural integrity to tissues that experience significant mechanical tension, including the heart. Deficiencies in desmosomal proteins lead to the development of arrhythmogenic cardiomyopathy (AC).
Here, we review clinical and mechanistic studies that provide insight into the functions of desmosomal proteins in skin and heart during homeostasis and in disease. While intercellular junctions are organized differently in cardiac and epithelial tissues, studies conducted in epithelial systems may inform our understanding of cardiac desmosomes.
have further highlighted the importance of desmosomes in cardiac tissue, where they help to maintain coordination of cardiac myocytes. Here, we review clinical and mechanistic studies that provide insight into the functions of desmosomal proteins in skin and heart during homeostasis and in disease.
22 mar 2023 · These studies highlight the importance of protein degradation pathways in ACM pathogenesis and the importance of fully functioning desmosomes in cardiac physiology.
