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6 sie 2022 · The etiology of breast cancer is a complex interplay between multiple risk factors including prior history of breast cancer, positive family history, obesity, tall stature, smoking, alcohol consumption, early menarche, late menopause, sedentary lifestyle, nulliparity and hormone replacement therapy.
23 sie 2022 · Etiology of breast cancer: A perspective from epidemiologic studies. Breast cancer is the most common cancer diagnosis worldwide, accounting for a quarter of new cancer diagnoses in women annually. In 2020, there were 2.3 million women newly-diagnosed with breast cancer and 7.8 million women living with a diagnosis within the past 5 years ...
20 sty 2021 · Results. Protein-truncating variants in 5 genes (ATM, BRCA1, BRCA2, CHEK2, and PALB2) were associated with a risk of breast cancer overall with a P value of less than 0.0001.
Breast cancer is highly heterogeneous in its pathological characteristics, some cases showing slow growth with excellent prognosis, while others being aggressive tumors. Current predictions and statistics suggest that both worldwide incidence of breast cancer and related mortality are on the rise.
2 lis 2022 · Epidemiologic research has established various risk factors which are significant in breast cancer aetiology and may be biological, behavioural, social, or physical. The risk factors include modifiable and non-modifiable elements, which act directly or indirectly and are often interrelated.
12 gru 2023 · Understanding the epidemiological characteristics of breast cancer including its incidence, prevalence, and mortality across different demographic and geographic aspects, as well as identifying the risk factors, could facilitate the development of proper public health policies.
28 sie 2019 · There is increasing evidence that breast cancer is a heterogeneous disease and that subtypes such as triple negative breast cancers may have a distinct etiology. Epidemiologic studies, family studies, and genome-wide association studies have identified several genetic variants and rare but moderate-to-high penetrance gene mutations that account ...
