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Photodynamic therapy is approved by the FDA for the treatment of actinic keratoses (AK), which are precancerous skin growths caused by sun-damaged cells in the epidermis (the skin’s outermost layer).
The dermatologist then uses a special red or blue light, a pulsed-dye laser or sometimes controlled natural sunlight to activate the medication and destroy the lesions, while causing minimal damage to surrounding healthy tissue. Some redness, peeling, flaking and swelling may result.
In mouse models of skin cancer, high-dose oral vitamin D3 (VD3; cholecalciferol) combined with photodynamic therapy (PDT) can improve the clearance of squamous precancers (actinic keratoses [AKs]).
Actinic keratoses (AK) are rough scaly patches that arise on chronically ultraviolet-exposed skin and can progress to keratinocyte carcinoma. This analysis examined the literature related to the management of AK to provide evidence-based recommendations for treatment.
Blue light photodynamic therapy (PDT) is effective for actinic keratosis, but many patients experience stinging pain during illumination. To compare a conventional regimen (1 hour of 5-aminolevulinic acid [ALA] preincubation, followed by blue light) ...
12 kwi 2023 · To the Editor: Therapies for actinic keratosis (AK) include photodynamic therapy (PDT), in which blue light activates photosensitizing compounds, like 5-aminolevulinic acid (5-ALA). 1 The approved incubation time for 5-ALA before light irradiation is 14-18 hours, with prior studies reporting 0-18 hours. 2,3 Nearly 10% of patients cannot complete...
22 mar 2022 · Background: In mouse models of skin cancer, high-dose oral vitamin D3 (VD3; cholecalciferol) combined with photodynamic therapy (PDT) can improve the clearance of squamous precancers (actinic keratoses [AKs]). Objective: To determine whether oral VD3 can improve the clinical efficacy of a painless PDT regimen in humans with AK.
