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A review of cost-effectiveness literature on the efficacy of oral bisphosphonates has shown alendronate and risedronate to be most cost-effective in women with low BMD without previous fractures. 9 Guidelines are inconsistent as to the place in therapy of denosumab (Prolia, Amgen).
Bisphosphonates (BPs) are a commonly used class of drugs for the treatment of bone disorders. An extensive review of BPs with their clinical efficacy and safety profile is unavailable. This study aimed to review the available literature on BPs, ...
5 lis 2019 · Alendronate is an option for maintaining or increasing bone mass, whereas risedronate is preferred in men with osteoporosis. [1] Off-Label Uses. Alendronate is used as an off-label medication for the below-mentioned conditions.
The results show that several bisphosphonates (zoledronic acid, pamidronate, and incadronate) reduce myeloma cell proliferation and induce apoptosis, while the nonnitrogen-containing compound, clodronate, has little or no effect.
11 lip 2017 · Alendronate sodium, the monosodium salt of alendronic acid, is an important member of the bisphosphonate class of drugs, which inhibits bone resorption by binding to bone surfaces and slowing down the formation of hydroxyapatite crystals.
17 maj 2021 · In this multicenter prospective, observational, postauthorization safety study conducted in Italy and Spain, postmenopausal women (PMW) with osteoporosis (naïve to bisphosphonates) were treated weekly with a buffered soluble alendronate 70 mg effervescent (ALN‐EFF) tablet (Binosto®) and followed for 12 ± 3 months.
1 mar 2022 · Innovation to improve oral absorption and other routes of delivery of the bisphosphonate drug class continues to be a goal, as their highly hydrophilic nature and metal chelation properties result in limited passage through lipophilic membranes.
