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3 dni temu · Currently, research on B cell mitochondria lags behind that of T cells, and there are still many untouched aspects like the role of MQC in B cells. In this review, we highlight advances that mitochondrial biogenesis, fission and fusion, mitophagy, and mtROS in the control of B cell differentiation, activation, and immune response.
9 gru 2011 · In this Review, we integrate this new information about each phase of antigen-specific B cell development to describe the newly unravelled molecular dynamics of memory B cell programming.
1 lut 2023 · In this review, we consider the three commonest indolent B-NHLs: follicular lymphoma, marginal zone lymphoma and Waldenstrom’s macroglobulinemia and review in detail the data on approved and emerging targeted therapeutic agents for each B-NHL subtype.
2 lut 2023 · Bispecific antibodies (BsAb) are a novel class of off-the-shelf T-cell redirecting drugs and are among the most promising immunotherapeutics for lymphoma today. BsAb may target various cell-surface antigens and exist in different formats.
1 cze 2023 · Reprogrammed B cells are successfully combating some extreme diseases through gene therapy (Fig. 6). In an experiment, reprogrammed B cells have been discerned to lessen the inflammation related to encephalitis in which the central nervous system gets damaged, and the neurons get demyelinated [175].
8 maj 2021 · Cazaubiel and colleagues review the current approaches that are being explored to adapt treatment strategies in MM considering, besides patient age and clinical disease presentation, a revised definition of high-risk groups and the presence of minimal residual disease (MRD).
21 paź 2022 · In this review, we start with an overview of BCR repertoire and related sequencing technologies and summarize their current applications in immune-mediated diseases. We also underscore the challenges of this emerging field and propose promising future directions in advancing BCR repertoire exploration. Graphical abstract. Subject areas.
