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8 sty 2024 · APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints. Article 25 September 2023. Introduction. Alzheimer disease (AD) is a neurodegenerative...
2 lis 2020 · APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer’s disease (AD). To address the underlying mechanism, we develop cerebral organoid models using induced...
19 cze 2024 · Nature Neuroscience - This Review provides a framework for incorporating APOE into Alzheimer’s disease (AD) clinical care by bridging recent advances in APOE and AD research with emerging...
12 wrz 2024 · His team found that people who inherited APOE4 from African ancestors have differences in surrounding DNA that lower the gene’s expression in brain cells compared with those who got it from European ancestors. That could explain why African American APOE4 carriers don’t face
10 lis 2015 · Apolipoprotein E (apoE) ɛ4 is associated with increases in both Aβ plaques and CAA in humans. Studies in mouse models that develop Aβ deposition have shown that murine apoE and human apoE4 have different abilities to facilitate plaque or CAA formation when studied independently.
Here, we review these scientific advances and propose a cell type-specific APOE4 cascade model of AD. In this model, neuronal APOE4 emerges as a crucial pathological initiator and driver of AD pathogenesis, instigating glial responses and, ultimately, neurodegeneration.
2 cze 2023 · At present, the study of neuronal ApoE4 has only explored its aggravation of Tau pathology, but how neuronal ApoE4 mediates pathological changes in other cells remains to be proven, and a stable method is found to specifically knock out the ApoE4 gene in neurons to improve pathological symptoms.
