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8 sty 2024 · APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints. Article 25 September 2023. Introduction. Alzheimer disease (AD) is a neurodegenerative disorder...
19 cze 2024 · Alzheimer’s disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) has remained...
8 maj 2020 · The apolipoprotein E ε4 allele (APOE* ε4) is indicated as a risk for Alzheimer's disease and other age-related diseases. The risk attributable to APOE* ε4 for depression is less clear and may be because of confounding of the relationship between dementia and depression. Aims.
Here, we review these scientific advances and propose a cell type-specific APOE4 cascade model of AD. In this model, neuronal APOE4 emerges as a crucial pathological initiator and driver of AD pathogenesis, instigating glial responses and, ultimately, neurodegeneration.
10 sty 2018 · Apolipoprotein E (APOE) is involved in the transport of cholesterol and other lipids between cellular structures. 1 It is genetically associated with two single-nucleotide polymorphisms (SNPs)...
4 lis 2020 · In order to understand these differences, we performed a qualitative systematic literature review of the reported cognitive and pathological differences between APOE4-positive (APOE4+) vs. APOE4-negative (APOE4−) AD patients.
2 cze 2023 · ApoE4 in neurons induces Aβ and tau protein pathologies, leading to neuroinflammation and neuronal damage, impairing learning and memory functions. However, how neuronal ApoE4 mediates AD pathology remains unclear. Recent studies have shown that neuronal ApoE4 may lead to greater neurotoxicity, which increases the risk of AD development.
