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Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure. Colorectal Dis 2013; 15 ( 1 ):19-26. [ PubMed ] [ Google Scholar ]
- The management of patients with primary chronic anal fissure: a ...
The goal of medical treatment for chronic anal fissure is to...
- Quality of compounded topical 2% diltiazem hydrochloride formulations ...
The use of topical 2% diltiazem hydrochloride for treating...
- The management of patients with primary chronic anal fissure: a ...
3 maj 2011 · The goal of medical treatment for chronic anal fissure is to achieve a temporary reduction of pressure of the anal canal, to facilitate the healing of the fissure (“reversible sphincterotomy”), thereby reducing muscle tone.
9 wrz 2013 · The use of topical 2% diltiazem hydrochloride for treating anal fissures by lowering anal sphincter pressure has been explored in multiple clinical trials since 2000[1-5]. Diltiazem hydrochloride, a calcium channel blocker, is well known as an oral treatment for hypertension and angina.
22 sty 2013 · In all, 9 studies have looked at how well diltiazem cream or ointment works for treating anal fissures. Only 1 of these studies looked at how well it worked compared with using no treatment. The anal fissure healed completely in 24 out of 30 adults who were using the diltiazem ointment compared with 10 out of 30 adults who were not using anything.
Anal fissures are considered to be acute if they have been present for less than 6 weeks, super - ficial and have well-demarcated edges. Most of the acute anal fissures heal spontaneously or with conservative medical management. Chronic anal fissures (CAF), on the other hand, persist for more than 6–8 weeks and
22 sty 2013 · The medicine is thought to work by helping the ring muscle (sphincter) that goes around the anus (back passage) to relax and allow blood to flow to the lining of the anus (back passage). This aids the healing process and relieves the pain (see 'What is a chronic anal fissure?').
GTN ointment is applied to the affected area twice a day and is used to relieve pain caused by the fissure. The GTN helps the ring muscle (sphincter) to relax which allows more blood to flow to the lining of the anus (back passage) so that the cells which make up the lining can heal the fissure (or tear).
