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1. www.nice.org.uk › advice › esuom32% Topical diltiazem hydrochloride for chronic anal fissure

   www.nice.org.uk › advice › esuom3

   An anal fissure is a common and often painful problem caused by a small tear or ulcer (open sore) in the lining of the anus (back passage). This can cause bleeding, local itching and pain with a bowel movement, which can be severe.

2. www.ncbi.nlm.nih.gov › pmc › articlesTopical treatments for anal fissure - PMC - National Center for...

   www.ncbi.nlm.nih.gov › pmc › articles

   How effective are topical treatments (calcium channel blockers [CCBs], nitrates, and vitamin E) for chronic anal fissures in adults?

3. www.io.nihr.ac.uk › diltiazem-hydrochloride-cream-for-treating-anal-fissuresDiltiazem hydrochloride cream for treating anal fissures

   www.io.nihr.ac.uk › diltiazem-hydrochloride-cream-for-treating-anal-fissures

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   Diltiazem hydrochloride cream is in clinical development for the treatment of chronic anal fissure. An anal fissure is a small tear or cut in the lining of the skin around the back passage (anus). The most common symptoms of anal fissures include pain around the anus and bleeding when passing stools.

4. www.nice.org.uk › advice › esuom3Chronic anal fissure: 2% topical diltiazem hydrochloride

   www.nice.org.uk › advice › esuom3

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   22 sty 2013 · The medicine is thought to work by helping the ring muscle (sphincter) that goes around the anus (back passage) to relax and allow blood to flow to the lining of the anus (back passage). This aids the healing process and relieves the pain (see 'What is a chronic anal fissure?').

5. www.openaccessjournals.com › articles › topical-diltiazem-in-management-of-chronicTopical diltiazem in management of chronic anal fissure: a review...

   www.openaccessjournals.com › articles › topical-diltiazem-in-management-of-chronic

   Anal fissures are considered to be acute if they have been present for less than 6 weeks, super - ficial and have well-demarcated edges. Most of the acute anal fissures heal spontaneously or with conservative medical management. Chronic anal fissures (CAF), on the other hand, persist for more than 6–8 weeks and

6. www.nice.org.uk › advice › esuom3Chronic anal fissure: 2% topical diltiazem hydrochloride

   www.nice.org.uk › advice › esuom3

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   22 sty 2013 · How well does topical diltiazem hydrochloride work? In all, 9 studies have looked at how well diltiazem cream or ointment works for treating anal fissures. Only 1 of these studies looked at how well it worked compared with using no treatment.

7. pubmed.ncbi.nlm.nih.gov › 11298624Topical diltiazem ointment in the treatment of chronic anal...

   pubmed.ncbi.nlm.nih.gov › 11298624

   Topical 2 per cent diltiazem ointment used as an agent for chemical sphincterotomy for chronic anal fissure offers significant healing rates but does not have a significant side-effect profile, which may aid compliance to treatment.