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The development of resistance went hand in hand with the introduction of new generations of penicillin into clinical practice (Figure 4). More than 150 antibiotics have been found since the discovery of penicillin, and for the majority of antibiotics available, resistance has emerged.
21 lis 2022 · Antimicrobial resistance (AMR) is a major global health challenge, causing substantial morbidity and death globally. Understanding the molecular mechanisms that underlie resistance can aid in...
12 cze 2024 · Antibiotic resistance (AMR) represents genetic and biochemical strategies that evade and overcome antibiotics. Abbas, Barkhouse et al. discuss how AMR is a survival trait evolved by bacteria over millennia and readily mobilized across bacterial populations; consequently, AMR is a fundamental threat to how we practice modern medicine and ...
1 cze 2024 · Resistant drug uptake, target site change, efflux pump mechanism, and target site mutation are examples of resistance mechanisms. The presence of resistant bacteria and antibiotic residues in the environment requires urgent global action to combat antimicrobial resistance (AMR).
29 mar 2017 · This perspective presents a historical account of the discovery of the wonder drug, describes the biological nature of penicillin, and considers lessons that can be learned from the golden era of antibiotic research, which took place between the 1940s and 1960s.
23 sie 2017 · In a PLOS Biology article, scientists show that intracellular expression of an antibiotic-metabolizing enzyme in a non-pathogenic strain of bacteria can provide resistance to the pathogen Streptococcus pneumoniae when the two types of bacteria are grown together, both in vitro and in vivo .
One key defense, the use of antibiotics, is beginning to fail worldwide because of the rise of antimicrobial resistance (AMR), which is threatening to undermine the practice of medicine (1–5). AMR is the ability of bacterial pathogens to survive exposure to compounds that were expected to kill them.
