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28 lip 2024 · Ampicillin, a commonly used beta-lactam antibiotic, has seen dwindling efficacy due to increasing resistance among various bacterial strains. Understanding how bacteria develop this resistance is crucial for developing new strategies to combat it and ensuring better clinical outcomes.
23 sie 2017 · In a PLOS Biology article, scientists show that intracellular expression of an antibiotic-metabolizing enzyme in a non-pathogenic strain of bacteria can provide resistance to the pathogen Streptococcus pneumoniae when the two types of bacteria are grown together, both in vitro and in vivo .
The journey of antibiotic development and resistance. Key dates for introduction of different penicillin classes and corresponding emergence of resistance are shown (top and bottom, respectively). Examples of different generations of penicillin are indicated and color-coded as in Figure 3.
13 paź 2021 · Resistance to Antibiotics: An Outline. Within a bacterial population, there is variation caused by mutations (as occurs in populations of all species) A chance mutation might cause some bacteria to become resistant to an antibiotic (eg. penicillin) When the population is treated with this antibiotic, the resistant bacteria do not die.
21 lis 2022 · Antimicrobial resistance (AMR) is a major global health challenge, causing substantial morbidity and death globally. Understanding the molecular mechanisms that underlie resistance can aid in...
29 mar 2017 · This perspective presents a historical account of the discovery of the wonder drug, describes the biological nature of penicillin, and considers lessons that can be learned from the golden era of antibiotic research, which took place between the 1940s and 1960s.
20 wrz 2010 · Arguably, the most specific and evolved mechanism of antibiotic resistance are enzymes that recognize antibiotics and modify them in such a way as to eliminate the functional characteristics that enable them to interact with their targets.
