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Two important aspects of gas exchange in the lung are ventilation and perfusion. Ventilation is the movement of air into and out of the lungs, and perfusion is the flow of blood in the pulmonary capillaries. For gas exchange to be efficient, the volumes involved in ventilation and perfusion should be compatible.
Pulmonary gas exchange can be investigated at different scales of interest. Our approach is to couple models of gas exchange to anatomically-detailed models of the airway and pulmonary vascular trees. We are linking a hierarchy of models from the capillary segment up...
9 gru 2020 · Different phenomena intervene in gas transfer, convection and diffusion in the gas, dissolution, diffusion across the alveolar-capillary membrane, diffusion across blood plasma, and finally diffusion and reaction with hemoglobin inside blood cells.
The model for structure-function correlation of the pulmonary gas exchanger so far discussed considered the whole lung: a gas-exchanging surface the size of a tennis court in humans with a capillary network containing ~200 mL of blood.
15 paź 2020 · This is achieved by exchanging these gases between blood and ambient air across the alveolar capillary membrane by the process of diffusion. In the microstructure of the lung, gas exchange is compartmentalized and happens in millions of microscopic alveolar units.
17 mar 2022 · Gas exchange is the process by which atmospheric oxygen (O 2) is transferred from the alveolar gas into the bloodstream and carbon dioxide (CO 2) from the bloodstream into the alveolar gas phase. CO 2 is then eliminated into the atmosphere by ventilation.
10 gru 2020 · Within this geometry, the model includes a method to calculate the gas flow distribution, the evaluation of the exchange fluxes of a gas species between the tissues and the lumen, and the computation of the concentration profile of the exchanged species in the lumen of the tracheobronchial tree.
