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18 kwi 2024 · Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is a common and potentially life-threatening condition due to its widespread availability and perceived safety. More than...
9 cze 2023 · This activity reviews the etiology, evaluation, and treatment of acetaminophen overdose and highlights the importance of the interprofessional team in both managing and preventing this problem. Objectives: Review the pathophysiology of acetaminophen toxicity. Describe the four clinical stages of acetaminophen toxicity.
3 maj 2024 · Acetaminophen (N-acetyl-para-aminophenol, paracetamol, APAP) toxicity is a common and potentially life-threatening condition due to its widespread availability and perceived safety. More than...
8 paź 2021 · There are roughly two patient populations with acetaminophen toxicity seen in the ICU: (1) Patients with liver failure due to acetaminophen poisoning. (2) Patients with polysubstance intoxication admitted to ICU for supportive care, who also happen to have a positive acetaminophen level.
The use of paracetamol in children requires special care and maintain in an adequate dosage (based on age), which significantly differs from standard adult. The recommended dosage for children consider the metabolism of paracetamol, which determines the toxicity of the drug, especially hepatotoxicity (see below).
13 sie 2024 · The pathophysiology, clinical manifestations, and diagnosis of acetaminophen toxicity in adults will be reviewed here. Treatment of this condition and evaluation of poisoning in children are discussed separately.
Acetaminophen in therapeutic doses (for adults 500–1000 mg, three to four times per day) has few adverse effects. However, overdose can result in acute liver injury (ALI), hepatotoxicity (defined as an alanine transaminase [ALT] or aspartate transaminase [AST] >1000 U/L), ALF, and death.
