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28 lut 2018 · An irregular Z line is characterized by < 1 cm columnar tongues that extend proximal to the gastroesophageal junction, a finding that has been reported in approximately 10–15% of the population undergoing upper endoscopy [1, 2].
Since gastroesophageal reflux is known to be of etiological importance in both Barrett's esophagus and esophageal adenocarcinoma, we aimed to study which endoscopic alterations at the Z-line can be attributed to a previous history of reflux symptoms.
Conclusions: The yield of biopsy at an “irregular z-line” is low. In addition, the risk of cancer in patients with this endoscopic finding and specialized intestinal metaplasia (even with dysplasia) is unknown.
3 lis 2022 · The Z line in the esophagus is the term for a faint zig-zag impression at the gastro-esophageal junction that demarcates the transition between the stratified squamous epithelium in the esophagus and the intestinal epithelium of the gastric cardia (the squamocolumnar junction).
8 sie 2022 · Given these risk factors, screening EGD is recommended. While appropriate screening was performed, biopsies were obtained from an irregular-appearing Z line. The current definition of BE requires columnar mucosa of at least 1 cm in length in conjunction with intestinal metaplasia on biopsies.
8 sie 2023 · The squamocolumnar junction, also referred as Z-line, is the area where the squamous epithelial lining of the esophagus (pale pink colored) meets the columnar lining mucosa of the stomach (salmon-colored).
Diagnosis, Screening, and Surveillance. Diagnosis. Diagnose Barrett's esophagus with salmon-colored mucosa >1 cm proximal to the GEJ + intestinal metaplasia on biopsy. Strong recommendation. Low quality evidence. Do not biopsy a normal Z-line or Z-line with <1 cm variability. Strong recommendation.
