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By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
10 sty 2022 · The development of pE-MAP and DMS enabled the systematic study of the relationship between genetic interactions and residue distances in a protein structure.
20 cze 2023 · The genetic map distance is roughly proportional to the physical distance, i.e. the amount of DNA between two loci. For example, in Arabidopsis , 1.0 cM corresponds to approximately 150,000bp and contains approximately 50 genes.
A genetic map shows the map distance, in cM, that separates any two loci, and the position of these loci relative to all other mapped loci. The genetic map distance is roughly proportional to the physical distance, i.e., the amount of DNA between two loci.
Calculate the map distance between loci given the phenotypes of offspring or predict phenotypes of offspring given the recombination frequency between loci. Use the distance to construct genetic maps based on data from two-point or three-point testcrosses.
4 maj 2024 · The proposed method predicts distance maps with a mean absolute error ( MAE) of 2.32Å and a root mean squared error ( RMSE) of 3.63Å on novel proteins. It predicts residue–residue distances more accurately than state-of-the-art structure prediction methods (ESMFold) with 3.74‰ inference time of it.
This lab’s research regarding gene linkage and recombination challenged the principle of independent assortment and led to a basic understanding of gene mapping.
