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By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
4 maj 2024 · The proposed method predicts distance maps with a mean absolute error ( MAE) of 2.32Å and a root mean squared error ( RMSE) of 3.63Å on novel proteins. It predicts residue–residue distances more accurately than state-of-the-art structure prediction methods (ESMFold) with 3.74‰ inference time of it.
30 kwi 2024 · genomeToProtein: maps genomic coordinates to positions within the sequence of the eventually encoded protein (s) in the genomic region. The function takes a GRanges as input and returns an IRangesList of the same length, each element ( IRanges) providing the coordinates within the respective protein’s sequence.
13 cze 2019 · Here we present VarMap, a web tool for mapping a list of chromosome coordinates to canonical UniProt sequences and associated protein 3D structures, including validation checks, and annotating them with structural information. Availability and implementation. https://www.ebi.ac.uk/thornton-srv/databases/VarMap. Supplementary information.
Here’s an example function that prints a table of the genomic, CDS, and protein coordinates given a coordinate mapper and a list of genomic values.
4 lis 2019 · Distances between proteins indicate how similar their expression patterns are. See www.proteomeHD.net for an interactive version of the map. n = 5,013 proteins.
17 kwi 2024 · Here, Zhu et al. develop a cross-linking mass spectrometry-based spatial proteomics method that does not require protein engineering, affords sub-organelle resolution, and elucidates both...