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By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
In this tutorial, we demonstrate gene-gene distance computation by selecting the genes expressed by 1% to 50% of cells among the top 500 variable genes. The expected running time for this computation is approximately 1 to 3 minutes.
29 kwi 2020 · Overall, we have shown the capabilities of SpaOTsc to (1) map between scRNA-seq data and spatial data, (2) infer spatial distances between single cells, (3) quantitatively compare spatial...
Calculating map distance between two genes is an indispensable tool in genetic research and molecular biology. By understanding recombination frequency and converting it into map distance, you can gain valuable insights into gene locations on a chromosome.
5 kwi 2024 · To visualize the geometry of all genes, we convert pairwise gene–gene Wasserstein distances into gene–gene affinities and use diffusion map to get a low-dimensional representation of genes.
First, let’s review how to calculate map distance in yeast: Consider and example of two linked genes, ARG3 and URA2 . P: arg3 ura2 x ARG3 URA2
In our framework, we have designed two strategies to accelerate the computation based on 1) cell graph coarse-graining, and 2) gene graph sparsification. Briefly, cell graph coarse-graining aims to reduce the cell number by aggregating nearest cells into “meta-cells”.
