Search results
26 kwi 2024 · We here review the epidemiology of aspirin hypersensitivity, provide an outline of pathophysiological mechanisms and clinical presentations, and review management options, starting from a characterization of true aspirin allergy—in contrast to intolerance—to suggestion of desensitization protocols.
6 lip 2004 · Proper classification of “ASA-allergic” patients and early referral to allergy services for potential ASA desensitization will allow use of this highly cost-effective therapy in cardiovascular patients.
8 maj 2024 · Proposed desensitization protocols vary; however, most involve administering increasing doses of aspirin over a time period (typically hours ranging to days) with or without pretreatment with agents such as antihistamines, antileukotrienes, and corticosteroids.
16 mar 2010 · Dosing was individualized for each patient and administered at intervals of 10–30 min, in the following increasing doses: 0.1 mg, 0.3 mg, 1 mg, 3 mg, 10 mg, 30 mg, 40 mg, 81 mg, 162 mg, and 325mg, although the latter two doses may be omitted depending on the final therapeutic dose required.
The rapid desensitization pro-tocol was based on an earlier pilot feasibility investigation performed by the same group.12 In the current protocol, 6 sequential doses of aspirin (1, 5, 10, 20, 40, and 100 mg) were administered orally over 5.5 hours.
5 paź 2013 · Effective daily dose of aspirin resulting in clinical improvement in patient with NERD varies from 300 to 1300 mg daily (grade of recommendation C) 94, 96, 100; Aspirin desensitization should be performed in a facility able to provide appropriate intensive care and constant observation by qualified and specialized staff (grade of recommendation D).
An economic analysis of outpatient aspirin desensitization and high-dose aspirin therapy found it to be a cost-effective therapeutic intervention for patients with moderate-to-severe AERD, even after accounting for the initial cost of the aspirin desensitization procedure.
