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By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
Gene mapping or genome mapping describes the methods used to identify the location of a gene on a chromosome and the distances between genes. Gene mapping can also describe the distances between different sites within a gene. The essence of all genome mapping is to place a collection of molecular markers onto their respective positions on the ...
A genetic map shows the map distance, in cM, that separates any two loci, and the position of these loci relative to all other mapped loci. The genetic map distance is roughly proportional to the physical distance, i.e., the amount of DNA between two loci.
A genetic map indicates the relative distance between genes or markers, represented by the recombination value and measured in cM. A physical map highlights the physical distance between genes or markers, the distance unit is a length unit, such as micrometers (μm) or base pair numbers (bp or kp).
A physical map provides detail of the actual physical distance between genetic markers, as well as the number of nucleotides. There are three methods scientists use to create a physical map: cytogenetic mapping, radiation hybrid mapping, and sequence mapping.
Explain the basis of sequence tagged site ( STS) mapping, and list the various DNA sequences that can be used as STSs. Describe how radiation hybrids and clone libraries are used in STS mapping. The next two chapters describe the techniques and strategies used to obtain genome sequences.
Calculate the map distance between loci given the phenotypes of offspring or predict phenotypes of offspring given the recombination frequency between loci. Use the distance to construct genetic maps based on data from two-point or three-point testcrosses.
