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By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
Consistent co-retention of a region of the genome and a human biochemical trait allows the genetic determinant of that trait to be assigned to a position on the cytogenetic map. More than 1,000 genes and other DNA sequences have now been assigned to positions on the cytogenetic map (McKusick, 1986).
A genetic map shows the map distance, in cM, that separates any two loci, and the position of these loci relative to all other mapped loci. The genetic map distance is roughly proportional to the physical distance, i.e., the amount of DNA between two loci.
Gene mapping or genome mapping describes the methods used to identify the location of a gene on a chromosome and the distances between genes. Gene mapping can also describe the distances between different sites within a gene. The essence of all genome mapping is to place a collection of molecular markers onto their respective positions on the ...
We present a combined experimental and analytic framework for high-precision, ultra-rich GI mapping and apply this platform to create a high-content, large-scale GI map of human genes that are diverse with respect to function and localization of the encoded proteins.
Since there are 24 different DNA molecules in the human genome, a complete human gene map consists of 24 maps, each in the linear form of the DNA molecule itself. One type of useful genome map is the messenger RNA (mRNA) or exon map.
Knowing the location of genes and the corresponding genetic traits they produce allows us to discover patterns of genomic organization with important functional consequences and to compare humans with other mammals. Detailed maps of the human genome should quickly lead to major human health benefits.
