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By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
The units of genetic distance are called map units (mu) or centiMorgans (cM), in honor of Thomas Hunt Morgan by his undergraduate student, Alfred Sturtevant, who developed the concept of genetic maps. Geneticists routinely directly convert the recombination frequencies of two loci into cM.
Genetic maps provide an outline for the location of genes within a genome, and they estimate the distance between genes and genetic markers on the basis of the recombination frequency during meiosis. Physical maps provide detailed information about the physical distance between the genes.
A genetic map shows the map distance, in cM, that separates any two loci, and the position of these loci relative to all other mapped loci. The genetic map distance is roughly proportional to the physical distance, i.e., the amount of DNA between two loci.
31 mar 2019 · Map distance is the distance between genes. To determine the distance between the genes for vestigial wing and black body, we must estimate the average number of crossovers in the gametes of the doubly heterozygous F1 females (vg+vg, b+b)
Mating experiments can be used to map the relative distance between linked genes. Learning Objectives. To understand why Mendel’s laws of inheritance do not apply to linked genes. To understand the linear arrangement of genes along a chromosome. To understand how meiosis and crossing over results in recombinant gametes.
Describe the different types of marker used to construct genetic maps, and state how each type of marker is scored. Summarize the principles of inheritance as discovered by Mendel, and show how subsequent genetic research led to the development of linkage analysis.
