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How far is it to drive from Orlando, Florida to Florida Keys? View a map with the driving distance between Orlando, FL and Florida Keys to calculate your road trip mileage.
Distance from Orlando, FL to Key West, FL. There are 276.32 miles from Orlando to Key West in south direction and 393 miles (632.47 kilometers) by car, following the Florida's Turnpike route. Orlando and Key West are 6 hours 37 mins far apart, if you drive non-stop .
Use the road trip planner to drive from Orlando to Florida Keys using the best route and find places to stop.
Travelmath helps you find driving distances based on actual directions for your road trip. You can get the distance between cities, airports, states, countries, or zip codes to figure out the best route to travel to your destination.
Get a quick answer: It's 344 miles or 554 km from Orlando to Florida Keys, which takes about 5 hours, 24 minutes to drive.