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4 maj 2024 · The proposed method predicts distance maps with a mean absolute error ( MAE) of 2.32Å and a root mean squared error ( RMSE) of 3.63Å on novel proteins. It predicts residue–residue distances more accurately than state-of-the-art structure prediction methods (ESMFold) with 3.74‰ inference time of it.
The goal is to map location of proteins and protein-protein interactions during key cell events. Uses techniques such as X-ray Tomography and optical fluorescence microscopy.
By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
20 maj 2021 · Therapeutic proteins are tailored that mainly involve three basic approaches: (1) therapeutic proteins are either chemically or genetically linked to another protein or polymer, (2) variation in the amino acid sequence of a therapeutic protein either by introducing a single or more mutations or deletions, (3) codon optimization in the ...
8 maj 2022 · Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins.
Genetic interactions capture functional relationships between genes using phenotypic readouts, while protein-protein interactions identify physical connections between gene products. These complementary, and largely non-overlapping, networks provide a global view of the functional architecture of a cell, revealing general organizing principles ...
In this field, researchers explore the molecular basis of various genetic processes, mapping genes on specific chromosomes, finding out the specific characters associated with those particular genes, isolation and characterization of the gene of interest, expressions of different genes and modification of specific genes with the help of genetic ...
