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15 lip 2021 · We have developed ORM, which, for the first time, allows genome-wide, high-throughput, single-molecule replication mapping in human cells. The approach is based on in vivo labeling of replication forks and in vitro detection and genomic
11 sty 2016 · An orthogonal method to map replication is based on the analysis of nucleotide compositional asymmetries of the two DNA strands 1,14,15.
14 paź 2008 · Using stringent purification of SNS by exonuclease digestion, we have developed a genome-wide mapping of replication origins based on hybridization of SNS to DNA microarrays, covering 30 Mb of the human genome.
25 lut 2019 · This protocol describes experimental and computational procedures for obtaining genome-wide DNA replication timing maps based on copy-number differences derived from whole-genome...
9 sie 2018 · We also identify strong GI correlations associated with canonical DNA replication genes such as between POLE2 and PRIM2 as well as POLD1, POLD3 and CACTIN (Figure 3 F).
A genetic map shows the map distance, in cM, that separates any two loci, and the position of these loci relative to all other mapped loci. The genetic map distance is roughly proportional to the physical distance, i.e., the amount of DNA between two loci.
31 gru 2018 · Although DNA replication is a fundamental aspect of biology, it is not known what determines where DNA replication starts and stops in the human genome. We directly identified and...
