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24 gru 2022 · Map distance is estimated from the observed recombination frequency using mapping functions, the most widely used of those, Haldane and Kosambi, being developed at the time when the number of...
5 mar 2024 · Development of single-cell whole-genome sequencing techniques has enabled us to amplify and sequence the diploid genome in a single cell to study the genetic heterogeneities within a...
By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
24 gru 2022 · These findings demonstrate that (intermediate) map distances must be interpreted with care and context-specifically. We also formulated a piecewise function that allows the association between map distance and recombination frequency to be ambiguous.
21 wrz 2023 · Identifying and characterizing mobile genetic elements in sequencing data is essential for understanding their diversity, ecology, biotechnological applications and impact on public health.
Calculate the map distance between loci given the phenotypes of offspring or predict phenotypes of offspring given the recombination frequency between loci. Use the distance to construct genetic maps based on data from two-point or three-point testcrosses.
Describe the different types of marker used to construct genetic maps, and state how each type of marker is scored. Summarize the principles of inheritance as discovered by Mendel, and show how subsequent genetic research led to the development of linkage analysis.
