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10 gru 2019 · The fetal fraction (FF) is a function of both biological factors and bioinformatics algorithms used to interpret DNA sequencing results. It is an essential quality control component of noninvasive prenatal testing (NIPT) results.
- Fetal fraction in maternal plasma cell‐free DNA at 11–13 weeks ...
Current NIPT methods require a fetal fraction of at least...
- Fetal fraction in maternal plasma cell‐free DNA at 11–13 weeks ...
2 dni temu · Fetal fraction is the term given to the proportion of cfDNA belonging to the placenta found in the mother’s blood. In order to perform NIPT, there must be a minimum level of fetal fraction (a minimum amount of placental cfDNA).
I think a GC may need to comment on whether the chance of a true positive is more likely with higher fetal fraction. Besides statistical false positives, there are also possibilities of confined placental mosaicism (placenta has monosomy X but fetus is XX), early twin demise, or maternal mosaicism.
27 sty 2022 · Fetal fraction, an important parameter in the analysis of noninvasive prenatal screening results, is the proportion of fetal cell-free DNA present in the total maternal plasma cell-free DNA. It combines biological factors and bioinformatics algorithms to interpret noninvasive prenatal screening results and is an integral part of quality control.
25 paź 2012 · Current NIPT methods require a fetal fraction of at least 4%. On the basis of the results of this study the greatest risk factor for low fetal fraction is obesity, with a small contribution from Afro-Caribbean origin and early gestational age.
12 gru 2023 · Fetal fraction is universally measured as a quality parameter in noninvasive prenatal testing (NIPT) for fetal aneuploidies. Given that fetal cell-free DNA originates from the placenta, the fetal fraction could reflect placental health and maternal pregnancy adaptation.
1 sty 2018 · The overall fetal fraction was 7.4%, and the mosaicism hence resulted in an effective fetal fraction of ~ 2.2%, which was too low for the NIPT test method used to detect the trisomy 18. In summary, in this section we have described the types, frequency, origins, and other clinical effects of CPM including its influence on cfDNA NIPT accuracy.
