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14 mar 2018 · Current national guidelines recommend against esophageal biopsy for assessment of precancerous Barrett esophagus (BE) in patients with an irregular Z line, i.e., <1 cm of irregular mucosa (NEJM JW Gastroenterol Feb 2016 and Am J Gastroenterol 2016; 111:30).
28 lut 2018 · The Z line demarcates the squamocolumnar junction (SCJ), the transition from the squamous esophageal mucosa to the columnar mucosa lining the stomach, or in cases of Barrett’s esophagus, between the squamous and intestinalized columnar epithelium of the metaplastic segment.
Conclusions: The yield of biopsy at an “irregular z-line” is low. In addition, the risk of cancer in patients with this endoscopic finding and specialized intestinal metaplasia (even with dysplasia) is unknown.
Since gastroesophageal reflux is known to be of etiological importance in both Barrett's esophagus and esophageal adenocarcinoma, we aimed to study which endoscopic alterations at the Z-line can be attributed to a previous history of reflux symptoms.
23 maj 2021 · Barrett’s esophagus (BE) is a known risk factor for esophageal adenocarcinoma (EAC) and consensus guidelines recommend a standardized approach to endoscopic screening and surveillance. Segments less than one centimeter are often described as an irregular Z line.
8 sie 2022 · Given these risk factors, screening EGD is recommended. While appropriate screening was performed, biopsies were obtained from an irregular-appearing Z line. The current definition of BE requires columnar mucosa of at least 1 cm in length in conjunction with intestinal metaplasia on biopsies.
8 sie 2023 · The squamocolumnar junction, also referred as Z-line, is the area where the squamous epithelial lining of the esophagus (pale pink colored) meets the columnar lining mucosa of the stomach (salmon-colored).
