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21 godz. temu · To discover functions for "orphan" transporters and enzymes -- proteins with unknown substrates -- the researchers developed the GeneMAP discovery platform. They used datasets from two independent ...
21 godz. temu · GeneMAP discovery platform will help define functions for ‘orphan’ metabolic proteins. The combination of genomics and metabolism identified a long-sought mitochondrial choline transporter. A multidisciplinary research team has developed a discovery platform to probe the function of genes involved in metabolism — the sum of all life ...
21 godz. temu · Introduction. Gene networks, constituted of nodes that represent genes or their expression products such as messenger ribonucleic acid (mRNA) transcripts and proteins, are intricately interconnected by edges that signify gene-to-gene pairing relationships [1, 2].Interactions among proteins within these networks are pivotal in orchestrating a range of cellular functions, encompassing signal ...
21 godz. temu · Metabolic reactions play critical roles in nutrient absorption, energy production, waste disposal, and synthesis of cellular building blocks including proteins, lipids and nucleic acids. About 20% of protein-coding genes are dedicated to metabolism, including genes that code for small-molecule transporters and enzymes, Gamazon said.
3 dni temu · Genetic mapping is the process of determining the order of and relative distance between genetic markers (specific sequences or heritable elements that generate a phenotype) on a...
5 dni temu · To define the relationship between the diverse signalling proteins recruited into myddosomes, we generated knockouts of genes encoding regulators of the NF-κB, MAP kinase and TBK1 pathways in our ...
2 dni temu · Mapping refers to the process of determining the relative locations of landmarks or markers (such as genes, variants and other DNA sequences of interest) within a chromosome or genome.
