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20 godz. temu · To discover functions for "orphan" transporters and enzymes -- proteins with unknown substrates -- the researchers developed the GeneMAP discovery platform. They used datasets from two independent ...
20 godz. temu · Metabolic reactions play critical roles in nutrient absorption, energy production, waste disposal, and synthesis of cellular building blocks including proteins, lipids and nucleic acids. About 20% of protein-coding genes are dedicated to metabolism, including genes that code for small-molecule transporters and enzymes, Gamazon said.
3 dni temu · Proteins that are involved in immunity rapidly evolve to adapt to pathogens. However, some eukaryotic immune proteins have been shown to originate from bacterial antiphage systems, which suggests ...
3 dni temu · Enhancers that can regulate these genes, including their coordinates, reference database and the distance between the center of the enhancer and the start of the gene. Proteins encoded by selected genes and the biological processes in which they participate. Proteins which interact with the encoded proteins of the selected genes.
4 dni temu · A physical map, as related to genomics, is a graphical representation of physical locations of landmarks or markers (such as genes, variants and other DNA sequences of interest) within a chromosome or genome. A complete genome sequence is one type of physical map.
20 godz. temu · GeneMAP discovery platform will help define functions for ‘orphan’ metabolic proteins. The combination of genomics and metabolism identified a long-sought mitochondrial choline transporter. A multidisciplinary research team has developed a discovery platform to probe the function of genes involved in metabolism — the sum of all life ...
2 dni temu · Historically, there have been two approaches for mapping: physical mapping, which established maps based on physical distances between landmarks, and genetic mapping, which established maps based on the frequency with which two landmarks are inherited together.
