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19 godz. temu · To discover functions for "orphan" transporters and enzymes -- proteins with unknown substrates -- the researchers developed the GeneMAP discovery platform. They used datasets from two independent ...
19 godz. temu · GeneMAP discovery platform will help define functions for ‘orphan’ metabolic proteins. The combination of genomics and metabolism identified a long-sought mitochondrial choline transporter. A multidisciplinary research team has developed a discovery platform to probe the function of genes involved in metabolism — the sum of all life ...
19 godz. temu · Metabolic reactions play critical roles in nutrient absorption, energy production, waste disposal, and synthesis of cellular building blocks including proteins, lipids and nucleic acids. About 20% of protein-coding genes are dedicated to metabolism, including genes that code for small-molecule transporters and enzymes, Gamazon said.
19 godz. temu · Background Recent studies uncovered pervasive transcription and translation of thousands of noncanonical open reading frames (nORFs) outside of annotated genes. The contribution of nORFs to cellular phenotypes is difficult to infer using conventional approaches because nORFs tend to be short, of recent de novo origins, and lowly expressed. Here we develop a dedicated coexpression analysis ...
3 dni temu · Genetic mapping is the process of determining the order of and relative distance between genetic markers (specific sequences or heritable elements that generate a phenotype) on a chromosome...
5 dni temu · To define the relationship between the diverse signalling proteins recruited into myddosomes, we generated knockouts of genes encoding regulators of the NF-κB, MAP kinase and TBK1 pathways in our ...
4 dni temu · Genes with > 1.5-fold higher expression in both the yap1∆ and skn7∆ mutants relative to wild type were enriched for amino acid biosynthesis (P = 2 × 10 –13). The 99 genes with higher expression in the skn7∆ mutant but not the yap1∆ mutant were enriched for those involved in iron ion transport (P = 3 × 10 –5).
