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4 dni temu · Spatial analysis of melanoma microenvironment gene expression at single-cell level identifies markers of malignancy and prognosis.
1 dzień temu · The Cancer Genome Atlas (TCGA) is a compendium of ‘maps’ detailing the genetic, epigenetic and molecular changes that occur during the pathogenesis of cancer, yet it lacks a dependency map to ...
1 dzień temu · In order for immune cells to effectively kill cancer cells, a triad of three cells are necessary — a dendritic cell, a cytotoxic “killer” T cell, and a helper T cell, researchers at MSK and Baylor College of Medicine have found. The discovery could alter the way doctors administer immunotherapies.
3 dni temu · Transfection of MAGE/GAGE gene into sensitive cancer cells drive the emergence of paclitaxel resistance in ovarian cancer cell line by 4-fold increase [ 105 ]. Acquisition of paclitaxel resistance related with increased expression of a variety of proteins and both neighboring and non-neighboring cancer antigens genes.
3 dni temu · The percent recombination between two linked genes can be directly converted into units of genetic distance called centi- Morgans or map units. While these genetic distances are only estimates of the true physical distance between two genes, they are still extremely valuable, as we will discuss in the Applications portion of the web site.
5 dni temu · By integrating into a bi-parental genome graph, the haplotypic assemblies can facilitate downstream short-reads-based SV calling and allele-specific gene expression analysis, demonstrating outstanding advantages over a single linear genome.
4 dni temu · New research from the National Institute of Genetics reveals how non-coding DNA regions, known as cis-regulatory elements, drive evolution. Using advanced techniques, scientists mapped these regions to uncover how gene regulation evolves, offering fresh insights into adaptation.
