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Mechanism of action. Atorvastatin is a statin medication and a competitive inhibitor of the enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol biosynthesis. 1,8 Atorvastatin acts primarily in the liver, where decreased hepatic ...
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Atorvastatin (DB01076) Fenofibrate (DB01039) Torcetrapib...
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Ezetimibe/Simvastatin (10 mg/40 mg) vs. the Doubling of...
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Atorvastatin: An HMG-CoA reductase inhibitor used to lower...
- Atorvastatin Completed Phase 3 Trials for Mixed Hyperlipidemia Treatment
Atorvastatin Completed Phase 3 Trials for Mixed...
- Atorvastatin Terminated Phase 4 Trials for Dyslipidemia
Atorvastatin Terminated Phase 4 Trials for Dyslipidemia -...
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Drug Drug Name Drug Description; DB12274: Aducanumab: A...
- Atorvastatin Completed Phase 4 Trials for Type 2 Diabetes Mellitus Treatment
Atorvastatin (DB01076) Omega-3 fatty acids (DB11133)...
- Atorvastatin Completed Phase 3 Trials for Primary Hypercholesterolemia / Mixed Dyslipidemias Treatment
Atorvastatin Completed Phase 3 Trials for Primary...
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8 cze 2024 · This activity reviews the indications, contraindications, and mechanism of action of atorvastatin to manage coronary heart disease and familial dyslipidemias, covering the indications, contraindications, activity, adverse events, and other key elements of atorvastatin therapy.
8 cze 2024 · This activity reviews the indications, contraindications, and mechanism of action of atorvastatin to manage coronary heart disease and familial dyslipidemias, covering the indications, contraindications, activity, adverse events, and other key elements of atorvastatin therapy.
The liver is the primary site of action of atorvastatin, as this is the principal site of both cholesterol synthesis and LDL clearance. It is the dosage of atorvastatin, rather than systemic medication concentration, which correlates with extent of LDL-C reduction.
29 lut 2024 · Statins are inhibitors of hydroxymethylglutaryl-CoA reductase enzyme and lower total cholesterol, low-density lipoprotein (LDL), and triglyceride concentrations. The FDA-approved statins include atorvastatin, rosuvastatin, simvastatin, pravastatin, fluvastatin, lovastatin, and pitavastatin.
23 kwi 2024 · Statins are lipid-lowering drugs that inhibit HMG CoA reductase, a key enzyme in cholesterol synthesis. They have beneficial effects on coronary heart disease prevention, but may cause muscle symptoms and other adverse reactions.
1 maj 2007 · The beneficial effects of statins are the result of their capacity to reduce cholesterol biosyntesis, mainly in the liver, where they are selectively distributed, as well as to the modulation of lipid metabolism, derived from their effect of inhibition upon HMG‐CoA reductase.
