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4 sie 2015 · An irregular Z-line in an esophageal ultrasound indicates an incorrect joining with the gastroesophageal junction at the base of the esophagus. Irregular Z-lines often lead to a diagnosis of Barrett’s esophagus, according to a study published by the National Institutes of Health.
28 lut 2018 · An irregular Z line is characterized by < 1 cm columnar tongues that extend proximal to the gastroesophageal junction, a finding that has been reported in approximately 10–15% of the population undergoing upper endoscopy [ 1, 2 ]. In those with an irregular Z line, there is up to a 44% prevalence of intestinal metaplasia (IM) [ 3 ].
3 lis 2022 · The Z line is a normal finding but is not seen in every study. An irregular or elevated Z line indicates potential distal esophageal metaplasia / Barrett esophagus, although the actual risk of this finding is debated.
21 maj 2024 · Irregular Z-line, defined as < 1 cm segment of columnar mucosa in distal esophagus, is commonly encountered and frequently biopsied. Consensus guidelines recommend against biopsies of irregular z-line due to low risk of progression to esophageal cancer (EAC).
A multicenter cohort study of 1,791 patients undergoing surveillance of BE defined as a columnar-lined esophagus with IM on biopsies and followed for a median of 5.9 years found that none of the 167 patients with an irregular Z line (<1 cm) developed HGD or cancer compared with 71 of 1,624 patients with BE ≥1 cm.
29 paź 2020 · If biopsies are sampled from an irregular Z-line, with no clear endoscopic evidence of Barrett’s, they should then be sent to the pathologist as z-line biopsies and not as endoscopically suspected Barrett esophagus (ESEM) biopsy samples.
8 lut 2023 · Barrett's esophagus is a condition in which the flat pink lining of the swallowing tube that connects the mouth to the stomach (esophagus) becomes damaged by acid reflux, which causes the lining to thicken and become red.
