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5 mar 2021 · Introduction. Pseudogenes are genic derived sequences that have lost the capability to encode a functional protein 1, 2, 3. Based on the intron-exon structure they are classified into two...
4 cze 2019 · Pseudogenes have long been defined as non-functional sequences of genomic DNA that are formed by duplication or retrotransposition and loss of gene function by subsequent disabling mutations. Pseudogene assignments are largely dependent on reliable and stable gene annotations within the genome.
4 cze 2019 · We have summary that pseudogenes can be function by being involved in the regulation of gene expression and generating genetic diversity (Figure 1). Plant genomes contain some pseudogenes that under strong constraints because they are import components of the genome.
13 lut 2019 · Pseudogenes (Ψs), nonfunctional relatives of functional genes, form by duplication or retrotransposition, and loss of gene function by disabling mutations. Evolutionary analysis provides clues to Ψ origins and effects on gene regulation.
17 gru 1991 · Pseudogenes are paralogs generated from ancestral functional genes (parents) during genome evolution, which contain critical defects in their sequences, such as lacking a promoter, having a premature stop codon or frameshift mutations.
Here, we summarized current knowledge on pseudogenes including the historical and recent progress, analyzes their essential roles in gene regulation in hope of further stimulating researches in plant species for understanding gene regulation and evolution.
Despite the enormous occurrence of pseudogenes in plants, the lack of experimental validation has contributed toward their unresolved roles in gene regulation. Contrarily, most of the studies associated with gene regulation have been mainly reported for humans, mice, and other mammalian genomes.
