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10 sty 2022 · The development of pE-MAP and DMS enabled the systematic study of the relationship between genetic interactions and residue distances in a protein structure.
4 maj 2024 · The proposed method predicts distance maps with a mean absolute error ( MAE) of 2.32Å and a root mean squared error ( RMSE) of 3.63Å on novel proteins. It predicts residue–residue distances more accurately than state-of-the-art structure prediction methods (ESMFold) with 3.74‰ inference time of it.
By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
GI mapping is often used to uncover new functions of genes, enabling a hierarchical organization of gene products into functional complexes and pathways, and to identify synthetic-lethal interactions with relevance to cancer combination therapy.
6 kwi 2022 · Writing in Nature, Faure et al. 1 report the first integrated method to globally map, quantify and distinguish the effects of mutations on allostery and protein stability. Their approach is...
24 lut 2023 · Exploring molecular evolution necessitates studying how species, genes, and proteins are related to each other in an evolutionary sense. Phylogenetic relationships can apply to species, genes, or proteins even within the same genome.
Explain why a map is an important aid to genome sequencing. Distinguish between the terms ‘genetic map’ and ‘physical map’. Describe the different types of marker used to construct genetic maps, and state how each type of marker is scored.
