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28 lut 2018 · An irregular Z line is characterized by < 1 cm columnar tongues that extend proximal to the gastroesophageal junction, a finding that has been reported in approximately 10–15% of the population undergoing upper endoscopy [1, 2].
21 maj 2024 · Irregular Z-line, defined as < 1 cm segment of columnar mucosa in distal esophagus, is commonly encountered and frequently biopsied. Consensus guidelines recommend against biopsies of irregular z-line due to low risk of progression to esophageal cancer (EAC).
A multicenter cohort study of 1,791 patients undergoing surveillance of BE defined as a columnar-lined esophagus with IM on biopsies and followed for a median of 5.9 years found that none of the 167 patients with an irregular Z line (<1 cm) developed HGD or cancer compared with 71 of 1,624 patients with BE ≥1 cm.
Conclusions: The yield of biopsy at an “irregular z-line” is low. In addition, the risk of cancer in patients with this endoscopic finding and specialized intestinal metaplasia (even with dysplasia) is unknown.
8 sie 2022 · Careful inspection of the esophagus and the gastric cardia (in antegrade and retroflexed views) using high-definition endoscopy and virtual chromoendoscopy is recommended. Surveillance biopsies should target the distal 2–5 cm of the esophagus and GEJ, with targeted sampling from any visible lesions.
23 mar 2023 · Answer: A proximal displacement of columnar mucosa above the esophagogastric junction for less than 1 cm is defined as an irregular Z line. This finding is not uncommon, with a prevalence varying between 5% and 20%, in patients undergoing upper GI endoscopy [ 13 ].
23 maj 2021 · Objectives: 1) Define the biopsy rate of the irregular Z line in patients with no known history of Barrett’s esophagus. 2) Characterize histopathologic findings in irregular Z line biopsies. 3) Describe surveillance recommendations at the time of endoscopy for patients with an irregular Z line.
