Search results
• Mapping reveals the relative order of genes, not the actual physical distance. • The most accurate maps are made by summing the genetic distances of genes lying close together (small intervals). One needs to connect genes that lie far apart through the genes that lie between them.
By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
A genetic map shows the map distance, in cM, that separates any two loci, and the position of these loci relative to all other mapped loci. The genetic map distance is roughly proportional to the physical distance, i.e., the amount of DNA between two loci.
Map distance over long chromosomes Map distances are always calculated for one pair of loci at a time. However, by combining the results of multiple pairwise calculations, a genetic map of many loci on a chromosome can be produced (Figure 10-3). A genetic map shows the map distance, in cM, that separates any
7 lis 2008 · We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.
Solutions to Genetics Problems This chapter is much more than a solution set for the genetics problems. Here you will find details concerning the assumptions made, the approaches taken, the predictions that are reasonable, and strategies that you can use to solve any genetics problem. The value of this chapter depends on you.
We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.
