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18 mar 2024 · For the IL-1 receptor family, we suggest consolidating the nomenclature that we report in Table 1, which is based on the previously proposed numbering system and that clearly defines the...
Summary. The interleukin-1 (IL-1) family of cytokines and receptors is unique in immunology because the IL-1 family and Toll-like receptor (TLR) families share similar functions. More than any other cytokine family, the IL-1 family is primarily associated with innate immunity.
20 cze 2019 · Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli. The basic mechanism of signal initiation is a stepwise process in which an agonist cytokine binds its cognate receptor.
1 wrz 2020 · In this review we will examine the current knowledge on the role of IL-1 family cytokines in autoimmune and chronic inflammatory and degenerative diseases, with a particular focus on their endogenous control mechanisms, mainly based on soluble receptors/inhibitors and receptor antagonists.
18 sty 2010 · Common sources of interleukin-1 (IL-1) family cytokines are shown. All IL-1 family members are secreted by epithelial cells; however, these are the predominant source of IL-33,...
1 sty 2020 · Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and secretion is governed by inflammatory caspases within signaling platforms called inflammasomes.
For the IL-1 receptor family, we suggest consolidating the nomenclature that we report in Table 1, which is based on the previ-ously proposed numbering system and that clearly defines the...
