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8 lip 2024 · Finally, we integrated this atlas with the previous single-cell chromatin accessibility dataset from 13 adult mouse tissues to delineate the developmental stage-specific gene regulatory programmes ...
8 lip 2024 · Single-cell multiomic analysis of the epigenome, transcriptome, and proteome allows for comprehensive characterization of the molecular circuitry that underpins cell identity and state. However, the holistic interpretation of such datasets presents a challenge given a paucity of approaches for systematic, joint evaluation of different modalities. Here, we present Panpipes, a set of ...
4 dni temu · Historically, there have been two approaches for mapping: physical mapping, which established maps based on physical distances between landmarks, and genetic mapping, which established maps based on the frequency with which two landmarks are inherited together.
19 cze 2024 · Here, we generate single-cell RNA-seq maps of neuroblastoma cell lines, patient-derived xenograft models (PDX), and a genetically engineered mouse model (GEMM).
3 dni temu · The percent recombination between two linked genes can be directly converted into units of genetic distance called centi- Morgans or map units. While these genetic distances are only estimates of the true physical distance between two genes, they are still extremely valuable, as we will discuss in the Applications portion of the web site.
6 dni temu · Here we address how gene expression is coordinated over long stretches of DNA that is embedded in a dense chromatin environment. We focus on a large DNA domain that contains thousands of tiny noncoding piRNA genes that are only expressed in germ cells. Our work demonstrates that a specific factor called USTC works with chromatin remodeling factors and with the core transcription complex to ...
3 lip 2024 · Plotting distance between sample peaks and genomic features, or distance from one set of peaks to another set of peaks
