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By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
4 maj 2024 · The proposed method predicts distance maps with a mean absolute error ( MAE) of 2.32Å and a root mean squared error ( RMSE) of 3.63Å on novel proteins. It predicts residue–residue distances more accurately than state-of-the-art structure prediction methods (ESMFold) with 3.74‰ inference time of it.
A genetic map shows the map distance, in cM, that separates any two loci, and the position of these loci relative to all other mapped loci. The genetic map distance is roughly proportional to the physical distance, i.e., the amount of DNA between two loci.
10 sty 2022 · The development of pE-MAP and DMS enabled the systematic study of the relationship between genetic interactions and residue distances in a protein structure.
To understand how meiosis and crossing over results in recombinant gametes. To predict the outcome of genetic crosses involving one, two or three linked genes. To draw a simple genetic map based upon data from test crosses.
Genetic maps provide an outline for the location of genes within a genome, and they estimate the distance between genes and genetic markers on the basis of the recombination frequency during meiosis. Physical maps provide detailed information about the physical distance between the genes.
This lab’s research regarding gene linkage and recombination challenged the principle of independent assortment and led to a basic understanding of gene mapping.
