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So, if we want to figure out the map distance between genes further apart than this, we must do so by adding the recombination frequencies of multiple pairs of genes, "building up" a map that extends between the two distant genes.
26 maj 2021 · Features learned from protein sequences by the LSTM-LM and from contact maps by the GCN lead to substantial improvements in protein function prediction, therefore enabling novel protein function ...
13 cze 2019 · Understanding the protein structural context and patterning on proteins of genomic variants can help to separate benign from pathogenic variants and reveal molecular consequences. However, mapping genomic coordinates to protein structures is non-trivial, complicated by alternative splicing and transcript evidence.
10 sty 2022 · To achieve a systems view, protein interaction networks map which proteins physically interact, while genetic interaction networks inform on the phenotypic consequences of perturbing these...
4 maj 2024 · The proposed method predicts distance maps with a mean absolute error ( MAE) of 2.32Å and a root mean squared error ( RMSE) of 3.63Å on novel proteins. It predicts residue–residue distances more accurately than state-of-the-art structure prediction methods (ESMFold) with 3.74‰ inference time of it.
4 lis 2019 · The co-regulation map (ProHD) covers fewer genes than STRING, BioGRID, IntAct and BioPlex 2, but covers many associations between those genes. b, Overlap between PPIs discovered by protein...
29 wrz 2023 · The ProteinCartography pipeline identifies proteins related to a query protein using sequence- and structure-based searches, compares all protein structures, and creates a navigable map that can be used to look at protein relationships and make hypotheses about function. Cite. Social. Download. Contents. last released. 3 weeks ago. Purpose.
