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28 lut 2018 · An irregular Z line is characterized by < 1 cm columnar tongues that extend proximal to the gastroesophageal junction, a finding that has been reported in approximately 10–15% of the population undergoing upper endoscopy [1, 2].
21 maj 2024 · Consensus guidelines recommend against biopsies of irregular z-line due to low risk of progression to esophageal cancer (EAC). Despite this, presence of irregular Z-line with or without intestinal metaplasia (IM), dysplasia or EAC is encountered in practice and clinical significance is unclear.
In order to determine which endoscopic alterations that can be attributed to a previous history of gastroesophageal reflux, three different endoscopic definitions of columnar-lined esophagus (CLE) were used: (1) ZAP I, An irregular Z-line with a suspicion of tongue-like protrusions; (2) ZAP II/III, Distinct, obvious tongues of metaplastic ...
Conclusions: The yield of biopsy at an “irregular z-line” is low. In addition, the risk of cancer in patients with this endoscopic finding and specialized intestinal metaplasia (even with dysplasia) is unknown.
Barrett's oesophagus should be endoscopically distinguished from an irregular Z-line, whereby the squamocolumnar junction appears with tongues of columnar epithelium shorter than 1 cm and with no confluent columnar-lined segment.
21 maj 2024 · outcomes of the irregular z-line: a systematic review and meta analysis Previous Article A RANDOMIZED CONTROL TRIAL COMPARING THE MIGRATION RATE AND COST-EFFECTIVENESS OF FULLY COVERED ESOPHAGEAL STENTS WITH AND WITHOUT ENDOSCOPIC SUTURE FIXATION
Furthermore, short-segment Barrett esophagus may manifest as an irregular Z line and consequently may be missed easily during endoscopy unless there is suspicion and biopsy specimens are taken . The histologic hallmark of intestinal metaplasia is needed to confirm the diagnosis of Barrett esophagus.
