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21 maj 2024 · Irregular Z-line, defined as < 1 cm segment of columnar mucosa in distal esophagus, is commonly encountered and frequently biopsied. Consensus guidelines recommend against biopsies of irregular z-line due to low risk of progression to esophageal cancer (EAC).
- Should We Biopsy an Irregular Z-Line? The Yield of Biopsy to Diagnose ...
Conclusions: The yield of biopsy at an “irregular z-line” is...
- Should We Biopsy an Irregular Z-Line? The Yield of Biopsy to Diagnose ...
Conclusions: The yield of biopsy at an “irregular z-line” is low. In addition, the risk of cancer in patients with this endoscopic finding and specialized intestinal metaplasia (even with dysplasia) is unknown.
28 lut 2018 · An irregular Z line is characterized by < 1 cm columnar tongues that extend proximal to the gastroesophageal junction, a finding that has been reported in approximately 10–15% of the population undergoing upper endoscopy [1, 2]. In those with an irregular Z line, there is up to a 44% prevalence of intestinal metaplasia (IM) .
A multicenter cohort study of 1,791 patients undergoing surveillance of BE defined as a columnar-lined esophagus with IM on biopsies and followed for a median of 5.9 years found that none of the 167 patients with an irregular Z line (<1 cm) developed HGD or cancer compared with 71 of 1,624 patients with BE ≥1 cm.
Barrett's oesophagus should be endoscopically distinguished from an irregular Z-line, whereby the squamocolumnar junction appears with tongues of columnar epithelium shorter than 1 cm and with no confluent columnar-lined segment.
29 paź 2020 · Biopsies of a normal or irregular z-line are not recommended. If biopsies are sampled from an irregular Z-line, with no clear endoscopic evidence of Barrett’s, they should then be sent to the pathologist as z-line biopsies and not as endoscopically suspected Barrett esophagus (ESEM) biopsy samples.
Dysplasia is a pre-cancer. Although the cells are abnormal, they do not have the ability to spread to other parts of the body. This condition can be treated. If you have Barrett’s esophagus, your pathology report will most likely mention dysplasia as well. If the report says “negative for dysplasia”…
