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28 cze 2023 · The ability to map trafficking for thousands of endogenous proteins at once in living cells would reveal biology currently invisible to both microscopy and mass spectrometry. Here, we report TransitID, a method for unbiased mapping of endogenous proteome trafficking with nanometer spatial resolution in living cells.
What is genetic linkage? When genes are on separate chromosomes, or very far apart on the same chromosomes, they assort independently. That is, when the genes go into gametes, the allele received for one gene doesn't affect the allele received for the other.
1 lip 2021 · However, the dynamics of protein interactions across physiological contexts remain poorly understood. Here, we develop a quantitative proteomic approach combining protein correlation profiling with stable isotope labeling of mammals (PCP-SILAM) to map the interactomes of seven mouse tissues.
18 sty 2019 · Mapping proteins with temporal and spatial variability in single cells will add important insights into cellular signalling dynamics.
28 maj 2014 · A draft map of the human proteome is presented here, accounting for over 80% of the annotated protein-coding genes in humans; some novel protein-coding regions, including translated pseudogenes ...
24 lis 2021 · To calibrate distances in the embeddings to physical distances in cells, we assembled a reference set of subcellular components with known or estimated diameters, from protein complexes of...
Network integration reveals fundamental connections involving key functional modules of eukaryotic cells, defining a core network of cellular function, which could be elaborated to explore cell-type specificity in metazoans. Go to: Mapping the global yeast genetic interaction network.
