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By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome.
A genetic map (or recombination map) is a representation of the linear order of genes (or loci), and their relative distances determined by crossover frequency, along a chromosome. The fact that such linear maps can be constructed supports the concept of genes being arranged in a fixed, linear order along a single duplex of DNA for each chromosome.
A particularly efficient method of mapping three genes at once is the three-point cross, which allows the order and distance between three potentially linked genes to be determined in a single cross experiment (Figure 11.3.2).
31 mar 2019 · Gene map distance: Gene map distance is the distance between points on a chromosome which can be estimated by counting the number of crossovers between them. Therefore, the distance between two points on the genetic map of a chromosome is the average number of crossovers between them.
24 gru 2022 · The linear function predicts recombination frequency equal to map distance, whereas the p 0 (k) gives the map distance per the total map length of the chromosome, which yields an underestimate...
Calculate the map distance between loci given the phenotypes of offspring or predict phenotypes of offspring given the recombination frequency between loci. Use the distance to construct genetic maps based on data from two-point or three-point testcrosses.
As Figure 13.4 shows, by using recombination frequency to predict genetic distance, we can infer the relative gene order on chromosome 2. The values represent map distances in centimorgans (cM), which correspond to recombination frequencies (in percent).
